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 The purpose of this study was to investigate the effect of sports entrepreneurship education on self-determination motivation and social well-being with the mediating role of skill literacy in sports science students. The method of the present study is descriptive and correlational. The statistical population of this study included all students of sports sciences of Islamic Azad University of Birjand in the number of 250 people who were selected as a statistical sample. To collect data, self-determined motivation questionnaires from Lonsdale et al. (2014), social welfare questionnaire from Keys questionnaire (1998), standard questionnaire for evaluating entrepreneurship education of students in Baghersad (2016) and skill literacy of Zabihi et al. (2015) were used. The reliability of the questionnaires was also confirmed by calculating Cronbach's alpha. The results showed that sports entrepreneurship training has a significant effect on skill literacy and social well-being with the mediating role of skill literacy in Birjand sports science students. It is suggested that the higher education officials and planners of the country pay special attention to trainings in order to create a self-determined desire and motivation while acquiring knowledge and skill literacy in designing and compiling training courses
and course resources.